OASIS® Extracellulaire Matrix


About ECM, an introduction

Extracellulaire Matrix (Biodesign)


Brochure OASIS Extracellulaire Matrix
Brochure OASIS Extracellulaire Matrix (verkleind)

NIEUW: Engelstalige productbrochure OASIS Extracellular Matrix

OASIS Product Information
OASIS Gebruiksaanwijzing  (meertalig)
OASIS Gids voor het aanbrengen en behandelen  (Nederlandstalig)
OASIS Application and Management Guide   (Engelstalig)

Website producent Cook Biotech

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OASIS – Mechanism of Action

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Clinical Evidence

Clinical Fact Sheet OASIS 2019

Art. 001  An extracellular matrix graft (Oasis®) for treating .. Etris_JoTV_2019
Art. 002  Cost-effectiviness of using  adjunctive porcine .. Guest_J Wound Care_2017
Art. 003  Clinico Economics Outcomes ..  Romanelli Res_2016
Art. 004  The Management of diabetic foot ulcers..  Cazzell_Adv WoundCare_2015
Art. 005  Effectiveness of an Extracellular Matrix Graft OASIS ..  JOVS_2005


OASIS BiologiQ Casuisistiek NL
Casus Ulcus Cruris Venosum WCS 2010-1-06
Pressure Ulcers
Traumatic Ankle Injury

Contact Burn 
Palmar Burn
Scald Burn
Chest Burn

Klinische Studies & Publicaties:

NIEUW: OASIS bij kankergerelateerde huidschade

Small Intestinal Submucosal Matrix as a Novel Reconstructive Option for Large Scrotal Defects_Somani AK
Small Intestinal Submucosa Matrix as a Novel Therapy for Wounds in Dystrophic_Somani AK
Skin cancer poster text _Somani AK


> Nihsen ES, Johnson CE, Hiles MC. Bioactivity of small intestinal submucosa and oxidized regenerated cellulose/collagen. Adv Skin Wound Care. 2008;21:479-486.
> Hodde J, Janis A, Hiles M. Effects of sterilization on an extracellular matrix scaffold: Part II. Bioactivity and matrix interaction. J Mater Sci Mater Med. 2007;18:545-550.
> Hodde JP, Badylak SF, Brightman AO, Voytik-Harbin SL. Glycosaminoglycan content of small intestinal submucosa: a bioscaffold for tissue replacement. Tissue Eng. 1996;2:209-217.
> Hurst RE, Bonner RB. Mapping of the distribution of significant proteins and proteoglycans in small intestinal submucosa by fluorescence microscopy. J Biomater Sci Polymer Ed. 2001;12:1267-1279.
> Hodde JP, Ernst DMJ, Hiles MC. An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix. J Wound Care. 2005;14:23-25.
> McDevitt CA, Wildey GM, Cutrone RM. Transforming growth factor-B1 in a sterilized tissue derived from the pig small intestine submucosa. J Biomed Mater Res A. 2003;67A:637-640.


> Nherera – An Overview of Clinical and Health Economic
> Carter MJ, Waycaster C, Schaum K, Gilligan AM. Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers. Value Health. 2014;17:801-813.
> Efficacious and Cost-Effective Use of SIS Wound Matrix Oasis…


> Cuenca-Pardo J, Peralta-Conde D. Quemaduras en cara tratadas con escisión temprana y cubiertas con matriz acelular. Cir Plastic. 2011;21:11-19.
> Glik J, Kawecki M, Kitala D, et al. A new option for definitive burn wound closure – pair matching type of retrospective case-control study of hand burns in the hospitalised patients group in the Dr Stanislaw Sakiel Centre for Burn Treatment between 2009 and 2015. Int Wound J. 2017;14:849-855.
> Salgado RM, Bravo L, García M, Melchor JM, Krötzsch E. Histomorphometric analysis of early epithelization and dermal changes in mid-partial-thickness burn wounds in humans treated with porcine small intestinal submucosa and silver-containing hydrofiber. J Burn Care Res. 2014;35:e330-e337.

Acute wonden

> Baldursson BT, Kjartansson H, Konradsdottir F, Gudnason P, Sigurjonsson GF, Lund SH. Healing rate and autoimmune safety of full-thickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: a non-inferiority study. Int J Low Extrem Wounds. 2015.
> Veerkamp P, Isaacs M, Somani A. Small intestinal submucosal matrix as a novel reconstructive option for large scrotal defects. Dermatol Surg. 2018;44:318-321.
> Yeh DD, Nazarian RM, Demetri L, et al. Histopathological assessment of OASIS Ultra on critical-sized wound healing: A pilot study. J Cutan Pathol. 2017;44:523-529.
> Zagrocki L, Ross A, Hicks A. Management of degloving injuries of the lower extremity: a case report of a forklift injury. Foot Ankle Spec. 2013;6:150-153.

Diabetische ulcera

> Benbow M. Oasis: an innovative alternative dressing for chronic wounds. Br J Nurs. 2001;10:1489-1492
> Cazzell SM, Lange DL, Dickerson JE Jr., Slade HB. The management of diabetic foot ulcers with porcine small intestine submucosa tri-layer matrix: A randomized controlled trial. Adv Wound Care. 2015;4:711-718.
> Frykberg RG, Hodde JP. Biomaterial Wound Matrix from Small Intestine Submucosa: Review and Efficacy in Diabetic Wound Healing. In Lee BY, ed. The Wound Management Manual. New York,NY: McGraw-Hill; 2005:290-297. (Chapter in a book; no abstract available.)
Gilligan AM, Waycaster CR, Landsman AL. Wound closure in patients with DFU: a cost-effectiveness analysis of two cellular/tissue-derived products. J Wound Care. 2015;24:149-156.
> Guest J, Weidlich D, Singh H, et al. Cost-effectiveness of using adjunctive porcine small intestine submucosa tri-layer matrix compared with standard care in managing diabetic foot ulcers in the US. J Wound Care 2017;26(Sup1):S12-S24
> Landsman A. Roukis TS. DeFronzo DJ, Agnew P, Petranto RD, Surprenant M. Living cells or collagen matrix: Which is more beneficial in the treatment of diabetic foot ulcers? Wounds. 2008;20:111-116.
> Martinson M, Martinson N. A comparative analysis of skin substitutes used in the management of diabetic foot ulcers. J Wound Care. 2016;25:S8-S17.
> Niezgoda JA, Van Gils CC, Frykberg RG, Hodde JP. Randomized clinical trial comparing Oasis Wound Matrix to Regranex Gel for diabetic ulcers. Adv Skin Wound Care. 2005;18:258-266.

Veneuze ulcera

> Demling RH, Niezgoda JA, Haraway GD, Mostow EN. Small Intestinal Submucosa Wound Matrix and Full-thickness Venous Ulcers: Preliminary Results. Wounds. 2004;16:18-22.
> Guest J, Rana K, Singh H, Vowden P. Cost-effectiveness of using a collagen-containing dressing plus compression therapy in non-healing venous leg ulcers. J Wound Care. 2018;27:68-78
> Hankin CS, Knispel J, Lopes M, Bronstone A, Maus E. Clinical and cost efficacy of advanced wound care matrices for venous ulcers. J Manage Care Pharm. 2012;18:375-384.
> Lown I, Kurt T, Tran H, et al. Does Bilayered Extracellular Matrix Technology Hasten Wound Healing in Venous Stasis Ulcers? A Retrospective Study. Wounds. 2005;17:27-31
> Marston WA, Sabolinski ML, Parsons NB, Kirsner RS. Comparative effectiveness of a bilayered living cellular construct and a porcine collagen wound dressing in the treatment of venous leg ulcers. Wound Rep Regen. 2014;22:334-340.
> Mostow EN, Haraway GD, Dalsing M, Hodde JP, King D; OASIS Venus Ulcer Study Group. Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial. J Vasc Surg. 2005;41:837-843.


> Beers PJ, Adgerson CN, Millan SB. Porcine tri-layer wound matrix for the treatment of stage IV pressure ulcers. JAAD Case Rep. 2016;2:122-124.
> NIEUW Brown-Etris M, Milne CT, Hodde JP. An extracellular matrix graft (Oasis® wound matrix) for treating full-thickness pressure ulcers: A randomized clinical trial. J Tissue Viability 2019;28:21-26.

Gemengde chronische ulcera

> Barendse-Hofmann MG, Steenvoorde P, van Doorn L, Jacobi CE, Oskam J, Hedeman PP. Extracellular Wound Matrix (OASIS®): Exploring the Contraindications. Results of Its Use in 32 Consecutive Outpatient Clinic Cases. Wounds. 2007;19:258-263.
> Barendse-Hofmann MG, van Doorn LP, Oskam J, Steenvoorde P. Extracellular matrix prevents split-skin grafting in selected cases. J Wound Care. 2007;16:455-458.
> Carson SN, Travis E, Overall K, Lee-Jahshan S. Using Becaplermin Gel with Collagen Products to Potentiate Healing on Chronic Leg Wounds. Wounds. 2003;15:339-345.
> Olivares-Escutia J, Delbouis-Molina A, Fernandez-Meso JN, et al. Tratamiento de derides con ulceracion cronica, mediante submucosa de intestine delgado. Informe de 20 casos. Rev Mex Ortop Truamatol. 2002;16:125-130.
> Rando T. Use of a biological extracellular matrix wound therapy to heal complex, chronic wounds. J Wound Care. 2009;18:70-74.

Chronische vasculaire ulcera

> Romanelli M, Dini V, Bertone M, Barbanera S, Brilli C. OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology. Int Wound J. 2007;4:3-7.
> Romanelli M, Dini V, Bertone MS. Randomized comparison of Oasis Wound Matrix versus moist wound dressing in the treatment of difficult-to-heal wounds of mixed arterial/venous etiology. Adv Skin Wound Care. 2010;23:34-38.
> Romanelli M, Gilligan AM, Waycaster CR, Dini V. Difficult-to-heal wounds of mixed arterial/venous etiology: a cost-effectiveness analysis of extracellular matrix. Clinicoecon Outcomes Res. 2016;8:153-161.

Gemengde wonden

>  AbouIssa A, Mari W, Simman R. Clinical usage of an extracellular, collagen-rich matrix: A case series. Wounds. 2015;27:313-318.
> Brown DFM, Jaffer FA, Baker JN, Gurol ME. Case records of the Massachusetts General Hospital. Case 28-2013. A 52-year-old man with cardiac arrest after an acute myocardial infarction. N Engl J Med. 2013;369:1.47-1054.
> PART 1 Brown-Etris M, Cutshall WD, Hiles MC. A New Biomaterial Derived from Small Intestine Submucosa and Developed into a Wound Matrix Device. Wounds. 2002;14:150-166.
> Part 2 Brown-Etris M, Cutshall WD, Hiles MC. A New Biomaterial Derived from Small Intestine Submucosa and Developed into a Wound Matrix Device. Wounds. 2002;14:150-166.
> Heiney J, Redfern R. Difficult leg wounds successfully closed with decortication, bioresorbable ECM and NPWT. J Wound Care. 2013;22:314-316.